Notes · Respiratory · 7 min read

Spirometry and lung function

Obstructive, restrictive or mixed — and what the transfer factor adds.

Key points

  1. Obstruction: FEV1/FVC below 0.7 (or below the lower limit of normal).
  2. Restriction: reduced FVC with a normal or high FEV1/FVC; confirm with reduced total lung capacity.
  3. A rise in FEV1 of 12% and 200 mL after a bronchodilator supports asthma.
  4. Low gas transfer (DLCO) with obstruction suggests emphysema.
  5. Low DLCO with restriction suggests interstitial lung disease; normal DLCO suggests a chest wall or neuromuscular cause.
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